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Endolysins are phage‐encoded enzymes that degrade the peptidoglycan layer of bacterial cell walls, a process essential for the release of progeny virions. Their ability to precisely cleave key bonds ...

The bacterial cell wall must be constantly remodeled in order to grow and divide. This involves the close coordination of lytic enzymes and peptidoglycan synthesis. Researchers led by Martin ...

A transporter which some bacteria use to recycle fragments of their cell wall has been discovered. Researchers found that the transporter controls resistance to certain kinds of cell-wall targeting ...

The figure illustrates bacterial cell wall synthesis as mediated by an enzyme called MraY (yellow/green). The enzyme modifies the cell wall building blocks (bricks) with a carrier lipid (cyan) so that ...

Antibiotic resistance is considered one of the most urgent health threats of our time. Common bacteria such as E. coli and Staphylococcus aureus are evolving defenses against the drugs doctors rely on ...

Researchers at Umeå University in Sweden, led by Professor Felipe Cava, have identified a new family of enzymes that creates a unique type of cross-linking between the building blocks of bacterial ...

Research published in PLOS Pathogens highlights a cell wall-driven trigger of joint inflammation, pointing to new ways to target Lyme arthritis ...

A small antibiotic called plectasin uses an innovative mechanism to kill bacteria. By assembling into large structures, plectasin latches onto its target on the bacterial cell surface comparable to ...