Unexpected role for HAND2 transcription factor in cardiac valve formation A research team led by Prof. Zeller and Dr. Zuniga from the University of Basel has identified the so-called HAND2 gene as a ...

Mechanisms of heart-valve disease often mimic processes observed in embryonic and early childhood development, including activation of valvular interstitial cell (VIC) phenotypes and remodeling of ...

A global research collaborative including Medical University of South Carolina investigators report in today's Science Translational Medicine that defects in the primary cilia of the developing fetus ...

Mitral valve prolapse (MVP) is a common congenital abnormality of the heart that can cause severe complications such as arrhythmias, heart failure, and sudden cardiac death. To date, the causes of MVP ...

Background Patients with severe aortic stenosis (AS) are at high risk of mortality, regardless of symptom status. Despite ...