A preclinical study has reported that simultaneous inhibition of cyclin-dependent kinases 2 and 4/6 produced durable tumour ...

A new preclinical study from researchers at The University of Texas MD Anderson Cancer Center, published in Nature ...

In a major advance for molecular biology and cancer research, scientists have uncovered the molecular mechanisms that control a key step during the activation of cyclin-dependent kinases (CDKs) – the ...

Yeast cells have long served as an invaluable model for deciphering the fundamentals of cellular dormancy and proliferation. Quiescence, a reversible state of cellular dormancy characterised by ...

Arteriovenous malformations, a hallmark of hereditary hemorrhagic telangiectasia, may be driven by endothelial cell-cycle acceleration via CDK6, suggesting potential for repurposing CDK6 inhibitors.

Cilia are evolutionarily conserved, microtubule-based organelles that project from the surface of most eukaryotic cells and play a central role in sensing ...