Tiny tweaks in DNA folding can have big effects. A study from Umeå University shows that even the most subtle changes in DNA's shape have an important influence on gene activity and energy production.

Although there are striking differences between the cells that make up your eyes, kidneys, brain and toes, the DNA blueprint ...

Estrogen is known as an important hormone, and it can control many cellular and bodily functions by regulating the activity of hundreds of genes. Scientists have now learned more about how estrogen ...

The genome is more than a linear code; it is a dynamic structure whose three-dimensional folding dictates how genes are regulated. Traditional sequencing technologies capture base-level variation but ...

Studying how single DNA molecules behave helps us to better understand genetic disorders and design better drugs. Until now however, examining DNA molecules one-by-one was a slow process.

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

His decoding of the blueprint for life with Francis H.C. Crick made him one of the most important scientists of the 20th century. He wrote a celebrated memoir and later ignited an uproar with racist ...

James D. Watson, whose co-discovery of the twisted-ladder structure of DNA in 1953 helped light the long fuse on a revolution in medicine, crimefighting, genealogy and ethics, has died, according to ...