The IGFL2 gene encodes a cytokine found in primates, which are closely related to humans. In the joint tissue of people with rheumatoid arthritis, peripheral helper T (Tph) cells express IGFL2, which ...

Scientists have discovered why the flu vaccine can perform poorly. They found that a specific type of immune cell, called T follicular helper cells, indirectly controls the anti-influenza response.

New findings reveal how cancer manipulates immune pathways and highlight therapeutic strategies to unleash T-cells against even the most resistant tumors. Study: Cancer cells impair monocyte-mediated ...

UBC researchers discover how to grow specialized immune cells for more accessible off-the-shelf cell therapies to treat cancer, autoimmune disorders and more. For the first time, researchers at the ...

CD4 T helper cells help the body fight infections by signaling other cells to attack germs. Without enough CD4 T cells, the body can't fight diseases like HIV and becomes immunocompromised. HIV ...

Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also—in a particular subset of T cells—cause mitochondrial stress, DNA damage and cell death, Vanderbilt ...

Three days post viral infection CD8 T cells (red) re-arrest with antigen presenting cells (cyan), where they are supplied with IL-2 by CD4 T cells (yellow), which migrate in a stop and go pattern. The ...

New research shows how a specially trained population of immune cells keeps the peace by preventing other immune cells from attacking their own. The study provides a better understanding of immune ...

The research groups led by Wolfgang Kastenmüller and Georg Gasteiger employed innovative microscopy techniques to observe how specific immune cells, known as T-cells, are activated and proliferate ...

Efficient T-cell engineering is crucial for the success of CAR T-cell therapy research, but it requires multiple labor-intensive steps, including T-cell isolation, activation, and transduction.