AZoLifeSciences on MSN
Lower IgG hinge controls antibody assembly and immune function
The lower hinge of immunoglobulin G (IgG), an overlooked part of the antibody, acts as a structural and functional control ...
FcRn protects IgG and albumin from catabolism, transports IgG across the placenta, and regulates IgG function. Blocking or augmenting FcRn can decrease autoimmune antibodies and enhance drug delivery.
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