The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins—yet it exists in large quantities. A research team from ...

Scripps Research postdoctoral researcher Kaushik Chanda explores the mechanisms by which non-coding transcripts modulate neuronal function and structural integrity during learning and memory loss.

Researchers at the University of Toronto have mapped the spatial distribution of around 700 long non-coding RNAs, otherwise known as lncRNAs, in the testes. The team discovered much higher levels of ...

In RNA molecules, the 5′ untranslated region (UTR) is located directly upstream of the start codon and plays a crucial role in post-transcriptional regulation by controlling RNA stability, cellular ...

Non-coding RNAs (ncRNAs) constitute a diverse class of RNA molecules that do not encode proteins but exert critical regulatory roles in virtually all aspects of cellular physiology. MicroRNAs (miRNAs) ...

The expression of genes has to be very carefully controlled by cells; serious problems can arise when genes are expressed in the wrong places, at the wrong times, or at the wrong levels, for some ...

Northwestern Medicine scientists have discovered that a specific long non-coding RNA activates oncogenic signaling pathways in prostate cancer cells and drives tumor progression, underscoring its ...

To understand the human genome, scientists focused on protein-coding genes and their functions for decades. This has given us invaluable knowledge about the inner workings of the human body. But that ...

circRNA, circular RNA; dsRNA, double-stranded RNA; lncRNA, long non-coding RNA; mRNA, messenger RNA; miRNA, microRNA; ncRNA, non-coding RNA; pre-miRNA, precursor ...

When a gene produces too much protein, it can have devastating consequences on brain development and function. Patients with an overproduction of protein from the chromodomain helicase DNA binding ...

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark ...