Intracellular peptides, generated predominantly via the ubiquitin–proteasome system, have emerged as critical modulators of cell signalling. These peptides play multifaceted roles, ranging from ...

A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled ...

A paper published in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key driver in ...

Cellular membrane proteins play many important roles throughout the body, including transporting substances in and out of the cell, transmitting signals, speeding up reactions and helping neighboring ...

Complex sugar-protein molecules that sense external messages to help a cell grow or respond to its environment can now be tracked and analysed, using a Nobel Prize-winning chemistry technique.

The four helices conserved across the Lipocone superfamily constitute a cone-like structure, with the helices tending to coalesce on one end and open out into a pocket on the other, lined by the ...

The novel biosensor technology used in this study can also be transferred to other so-called G protein-coupled receptors (GPCRs), which act as crucial “signal receivers” in our cells and are of major ...

Scientists at the Ruđer Bošković Institute (RBI) in Zagreb, Croatia, have discovered that the protein CENP-E, long believed to act as a motor dragging chromosomes into place during cell division, in ...

DONGGUAN, China, Dec. 23, 2025 /PRNewswire/ -- Fapon Biopharma, a biotech in developing therapeutic biologics including cytokine-antibody fusion proteins and T-cell engagers, announced the publication ...

Ascentage Pharma receives US FDA’s IND clearance for BTK degrader APG-3288 to treat patients with relapsed/refractory B-cell malignancies: Rockville, Maryland Friday, January 9, ...