Scientists have determined how the SWI/SNF chromatin remodeling complex helps cancer cells 'remember' how to be cancerous after division. When a cell divides, it retains information about how to grow ...
A phase IB study of the combination of selumetinib (AZD6244, ARRY-142886) and cyclosporin A (CsA) in patients with advanced solid tumors with an expansion cohort in metastatic colorectal cancer (mCRC) ...
Methylated DNA markers (MDMs) in primary (pCRC) and metastatic colorectal cancers (mCRC). Prognostic stromal and immune response expression patterns in early-stage colorectal cancer predicted by genes ...
In a recent article published in Nature Genetics, researchers showed that mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) chromatin remodeling complexes represent a potential class of ...
Like wrenches made of Legos, SWI/SNF chromatin remodeling complexes tighten or loosen DNA in our cells to control how genes are turned on and made into proteins. When assembled correctly, these ...
Scientists at St. Jude Children’s Research Hospital found that subunits of the SWI/SNF chromatin remodeling complex, which is mutated in 20% of all cancers, help cells maintain a memory of ...
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