“This article illuminates the biology behind EDG-5506, demonstrating that modulation of fast skeletal muscle contraction protects against muscle injury, degeneration and fibrosis in models of DMD,” ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

The sarcoplasmic reticulum (SR) is a specialised organelle in skeletal muscle fibres that plays a pivotal role in regulating calcium dynamics crucial for muscle contraction and relaxation. Acting as ...

In a serendipitous discovery, UC San Diego researchers using cryo-EM technology captured the first visualizations of the 3-D structure of the muscle acetylcholine receptor in fetal and adult muscles.

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

Skeletal muscle mechanics and force generation are governed by complex interactions between contractile proteins and passive structural elements. At the cellular level, the sarcomere – the fundamental ...

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also ...

New research uncovers how fat hidden in your muscles could be a silent threat to your heart, offering a fresh perspective on cardiovascular risk beyond the scale. Study: Skeletal muscle adiposity, ...

Muscle relaxers help reduce muscle stiffness and pain from conditions like cerebral palsy and lower back pain. There are two main types of muscle relaxers: antispastics and antispasmodics. Muscle ...