New mutations in TP53 gene drive resistance to p53-targeted cancer therapy

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for ...

Scientists identify pre-cancerous states in seemingly normal aging tissues

A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the ...
EurekAlert!

Researchers uncover how tumors become resistant to promising p53-targeted therapy

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for therapeutics. Among them, the Y220C mutation is the ninth most frequent and it ...
Science Daily

Study finds surprising way that genetic mutation causes Huntington's disease, transforming understanding of the disorder

Scientists have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of brain cells. The findings change the understanding ...
mskcc.org

Using Only Immunotherapy Successfully Treats Several Cancers With MMRd Mutation, Improves Quality of Life

Maureen Sideris, seated, with her sister Marion, receiving the 8th of 9 immunotherapy infusions during successful treatment for early-stage gastroesophageal junction cancer at Memorial Sloan Kettering ...
Wired

For the First Time, Mutations in a Single Gene Have Been Linked to Mental Illness

Research links variations in the gene GRIN2A to a higher risk of developing schizophrenia and other forms of mental illness. The GRIN2A gene regulates communication between neurons by producing the ...