A variety of mutations in lentiviral vector expression systems have been shown to generate a non-integrating phenotype. We studied a novel 12 base-pair U3-long terminal repeats (LTR) integrase (IN) ...
A recent clinical trial in two adult X-CGD patients incorporated partially ablative busulfan conditioning before the infusion of autologous CD34+ cells transduced with the SF71gp91 phox γ-retroviral ...
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